CFHR5

Across TCGA patient cohorts, CFHR5 mutation is significantly associated with the RNA expression of many other genes, with 4,639 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CFHR5-associated genes across cancer lineages are SASS6, MIS18A, and KLC2. Each is linked with CFHR5 in more than 3 cancer types. Because this analysis shows association rather than direction, both CFHR5-to-partner and partner-to-CFHR5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SASS6 grouped by CFHR5-low versus CFHR5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CFHR5→partner) and Y-score (partner→CFHR5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SASS6 →	+0.462	+2.601	.003	<.001	3	4
UCEC	MIS18A →	+0.583	+2.115	<.001	<.001	3	4
LUSC	KLC2 →	+0.491	+2.514	.001	.001	3	4
UCEC	EIF2B3 →	+0.327	+1.836	.002	.001	3	4
UCEC	RAD54L →	+0.687	+2.753	<.001	<.001	3	4
UCEC	CDCA5 →	+0.786	+2.443	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,639 associations by consensus.

SASS6 by CFHR5 expression — UCEC

Explore this box plot interactively →