CFHR5

Across TCGA patient cohorts, CFHR5 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CFHR5-associated genes across cancer lineages are 4E-BP1, eEF2, and Axl. Each is linked with CFHR5 in more than 3 cancer types. Because this analysis shows association rather than direction, both CFHR5-to-partner and partner-to-CFHR5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by CFHR5-low versus CFHR5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CFHR5→partner) and Y-score (partner→CFHR5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.306	+2.807	<.001	.002	3	4
UCEC	eEF2 →	+0.307	+2.321	.011	.005	3	3
SKCM	Axl →	+0.384	+1.889	.025	.028	3	2
SKCM	ASNS →	+0.314	+1.807	.030	.022	3	2
UCEC	eIF4E →	+0.176	+1.807	.014	.004	3	2
UCEC	Heregulin →	-0.128	-1.807	.002	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

4E-BP1 by CFHR5 expression — UCEC

Explore this box plot interactively →