CFHR4

Across TCGA patient cohorts, CFHR4 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,596 significant associations in total. STAD shows the largest number of these associations.

The most reproducible CFHR4-associated GO terms across cancer lineages are Meiotic spindle organization, Mitotic cytokinesis, and Regulation of microtubule-based process. Each is linked with CFHR4 in more than 12 cancer types. Because this analysis shows association rather than direction, both CFHR4-to-partner and partner-to-CFHR4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Meiotic spindle organization grouped by CFHR4-low versus CFHR4-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CFHR4→partner) and Y-score (partner→CFHR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Meiotic spindle organization →	+0.064	+0.320	<.001	<.001	3	13
STAD	Mitotic cytokinesis →	+0.060	+0.193	<.001	<.001	3	13
ESCA	Regulation of microtubule-based process →	+0.054	+0.431	<.001	<.001	3	13
STAD	Intracellular protein transmembrane transport →	+0.051	+0.169	<.001	<.001	3	13
STAD	Metaphase chromosome alignment →	+0.065	+0.224	<.001	<.001	3	13
STAD	Protein transmembrane transport →	+0.052	+0.129	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,596 associations by consensus.

Meiotic spindle organization by CFHR4 expression — ESCA

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