CFHR4

Across TCGA patient cohorts, CFHR4 mutation is significantly associated with the RNA expression of many other genes, with 3,148 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CFHR4-associated genes across cancer lineages are B3GALNT2P1, LINC01034, and DSN1. Each is linked with CFHR4 in more than 2 cancer types. Because this analysis shows association rather than direction, both CFHR4-to-partner and partner-to-CFHR4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, B3GALNT2P1 grouped by CFHR4-low versus CFHR4-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CFHR4→partner) and Y-score (partner→CFHR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	B3GALNT2P1 →	+0.066	+5.201	<.001	.007	3	3
CESC	LINC01034 →	+0.191	+5.010	<.001	.009	3	3
UCEC	DSN1 →	+0.421	+2.423	.008	.001	3	3
UCEC	NCAPD3 →	+0.646	+2.671	<.001	<.001	3	3
UCEC	CENPU →	+0.625	+1.684	.001	.003	3	3
UCEC	FGD5 →	-0.640	-2.742	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,148 associations by consensus.

B3GALNT2P1 by CFHR4 expression — CESC

Explore this box plot interactively →