CFHR3

Across TCGA patient cohorts, CFHR3 protein abundance is significantly associated with the RNA expression of many other genes, with 12,756 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CFHR3-associated genes across cancer lineages are VEGFC, ESM1, and SNAI1. Each is linked with CFHR3 in more than 5 cancer types. Because this analysis shows association rather than direction, both CFHR3-to-partner and partner-to-CFHR3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CFHR3 versus VEGFC in CCRCC, with a Pearson correlation of 0.41.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CFHR3→partner) and Y-score (partner→CFHR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	VEGFC →	+1.088	+0.663	<.001	<.001	3	6
GBM	ESM1 →	+1.124	+0.661	<.001	<.001	3	5
CCRCC	SNAI1 →	+0.997	+0.553	<.001	<.001	3	5
PDAC	TREM1 →	+0.879	+0.704	<.001	<.001	3	4
LSCC	DLL4 →	+0.677	+0.469	<.001	<.001	3	4
GBM	CD300A →	+0.941	+0.849	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,756 associations by consensus.

CFHR3 vs VEGFC — CCRCC

Explore this scatter interactively →