CFHR3

Across TCGA patient cohorts, CFHR3 mutation is significantly associated with the RNA expression of many other genes, with 2,409 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CFHR3-associated genes across cancer lineages are SLC7A6OS, CMC2, and PRIMPOL. Each is linked with CFHR3 in more than 2 cancer types. Because this analysis shows association rather than direction, both CFHR3-to-partner and partner-to-CFHR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC7A6OS grouped by CFHR3-low versus CFHR3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CFHR3→partner) and Y-score (partner→CFHR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SLC7A6OS →	+0.469	+2.491	<.001	<.001	3	3
UCEC	CMC2 →	+0.582	+3.584	<.001	<.001	3	3
UCEC	PRIMPOL →	+0.483	+3.828	<.001	<.001	3	3
UCEC	SLC3A2 →	+0.411	+2.931	.001	<.001	3	3
UCEC	HEXIM2 →	+0.444	+1.938	<.001	.009	3	3
UCEC	SNHG30 →	+0.451	+1.773	.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,409 associations by consensus.

SLC7A6OS by CFHR3 expression — UCEC

Explore this box plot interactively →