CFHR3

Across TCGA patient cohorts, CFHR3 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CFHR3-associated genes across cancer lineages are ACC1, NDRG1_pT346, and XBP1. Each is linked with CFHR3 in more than 2 cancer types. Because this analysis shows association rather than direction, both CFHR3-to-partner and partner-to-CFHR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACC1 grouped by CFHR3-low versus CFHR3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CFHR3→partner) and Y-score (partner→CFHR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ACC1 →	+0.316	+2.472	.013	.010	2	3
SKCM	NDRG1_pT346 →	-0.541	-1.807	.045	.026	3	2
SKCM	XBP1 →	-0.270	-1.807	.007	.026	3	2
SKCM	ERK2 →	-0.228	-2.304	.008	.032	3	1
SKCM	PEA-15_pS116 →	-0.242	-1.874	.046	.049	3	1
SKCM	SF2 →	+0.149	+3.203	.008	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

ACC1 by CFHR3 expression — SKCM

Explore this box plot interactively →