CFHR3

Across TCGA cell cohorts, CFHR3 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,685 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CFHR3-associated GO terms across cancer lineages are Translational initiation, Adenylate cyclase-modulating G protein-coupled receptor signaling pathway, and Negative regulation of translation. Each is linked with CFHR3 in more than 7 cancer types. Because this analysis shows association rather than direction, both CFHR3-to-partner and partner-to-CFHR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Translational initiation grouped by CFHR3-low versus CFHR3-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CFHR3→partner) and Y-score (partner→CFHR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Translational initiation →	+0.113	+1.509	<.001	<.001	3	8
URINARY_TRACT	Adenylate cyclase-modulating G protein-coupled receptor signaling pathway →	-0.043	-0.488	.002	.004	3	8
OESOPHAGUS	Negative regulation of translation →	+0.047	+0.646	.007	.006	3	7
STOMACH	Cytoplasmic translation →	+0.101	+0.678	<.001	.003	3	7
URINARY_TRACT	Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway →	+0.110	+0.368	<.001	.002	3	7
STOMACH	Regulation of mRNA catabolic process →	+0.063	+0.548	.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,685 associations by consensus.

Translational initiation by CFHR3 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →