CFHR3

Across TCGA cell cohorts, CFHR3 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CFHR3-associated genes across cancer lineages are KRTAP19-6 and OR4F5. Each is linked with CFHR3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CFHR3-to-partner and partner-to-CFHR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP19-6 grouped by CFHR3-low versus CFHR3-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CFHR3→partner) and Y-score (partner→CFHR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	KRTAP19-6 →	+0.140	+4.643	<.001	.008	3	1
LARGE_INTESTINE	OR4F5 →	+0.029	+3.930	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

KRTAP19-6 by CFHR3 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →