CFHR2

Across TCGA pan-cancer cohorts, CFHR2 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it the most broadly survival-associated CFHR2 data layer compared with 4 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher CFHR2 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated CFHR2 expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

UCEC, LSCC, and CCRCC are the cancer types where CFHR2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Quartile	All	0.872	1.000	.024	16	view →
LSCC	DFS	Median	II,III,IV	0.836	1.000	.005	10	view →
CCRCC	DFS	Tertile	II,III,IV	0.270	1.000	.013	8	view →
PDAC	OS	Tertile	IV	0.836	0.491	.024	6	view →
HNSC	DFS	Median	IV	0.553	0.753	.038	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

CFHR2–UCEC (OS)

Open the UCEC breakdown →