Across TCGA pan-cancer cohorts, CFD mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated CFD data layer compared with 28 for mass-spec protein and 1 for mutation status.
The strongest signal is observed in colon adenocarcinoma (COAD), where higher CFD mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CFD expression acts as an unfavorable survival marker.
COAD, LSCC, and LUAD are the cancer types where CFD mass-spec protein most reproducibly stratifies survival.
mass-spec protein survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.