CFB

Across TCGA cell cohorts, CFB mutation is significantly associated with the RNA expression of many other genes, with 718 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CFB-associated genes across cancer lineages are OR2J2, PRAMEF18, and FAM24A. Each is linked with CFB in more than 2 cancer types. Because this analysis shows association rather than direction, both CFB-to-partner and partner-to-CFB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2J2 grouped by CFB-low versus CFB-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CFB→partner) and Y-score (partner→CFB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	OR2J2 →	+0.012	+4.139	.006	.001	3	3
SOFT_TISSUE	PRAMEF18 →	+0.026	+4.930	<.001	.008	3	2
PANCREAS	FAM24A →	+0.050	+4.029	<.001	.007	3	2
URINARY_TRACT	NMUR1 →	+0.125	+3.963	.009	.008	3	2
BLOOD_Lymphoma	OR6V1 →	+0.014	+3.169	<.001	.008	3	2
BLOOD_Leukemia	YWHAE →	+0.562	+3.614	.004	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 718 associations by consensus.

OR2J2 by CFB expression — PANCREAS

Explore this box plot interactively →