CFAP61

Across TCGA patient cohorts, CFAP61 mutation is significantly associated with the RNA expression of many other genes, with 6,594 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CFAP61-associated genes across cancer lineages are PARPBP, SNRPGP2, and EZH2. Each is linked with CFAP61 in more than 5 cancer types. Because this analysis shows association rather than direction, both CFAP61-to-partner and partner-to-CFAP61 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PARPBP grouped by CFAP61-low versus CFAP61-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CFAP61→partner) and Y-score (partner→CFAP61) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PARPBP →	+0.442	+1.547	<.001	<.001	3	6
STAD	SNRPGP2 →	+0.610	+3.472	.001	.002	2	6
HNSC	EZH2 →	+0.743	+3.333	.005	.005	3	5
LUAD	SNRPD1 →	+0.420	+2.520	.004	.009	3	5
UCEC	VBP1 →	+0.426	+2.010	<.001	.001	3	5
UCEC	SPC24 →	+0.395	+1.129	.009	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,594 associations by consensus.

PARPBP by CFAP61 expression — UCEC

Explore this box plot interactively →