CFAP58

Across TCGA patient cohorts, CFAP58 mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CFAP58-associated genes across cancer lineages are 14-3-3_beta, c-Kit, and Cyclin-B1. Each is linked with CFAP58 in more than 2 cancer types. Because this analysis shows association rather than direction, both CFAP58-to-partner and partner-to-CFAP58 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by CFAP58-low versus CFAP58-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CFAP58→partner) and Y-score (partner→CFAP58) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	14-3-3_beta →	-0.113	-1.415	.019	.045	3	3
SKCM	c-Kit →	-0.552	-2.459	.024	.017	3	3
UCEC	Cyclin-B1 →	+0.612	+1.754	<.001	.001	3	3
UCEC	p38-MAPK_pT180_Y182 →	-0.320	-1.392	.018	.017	3	3
UCEC	MEK1 →	+0.445	+2.273	<.001	<.001	3	2
UCEC	STAT3_pY705 →	-0.409	-1.584	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

14-3-3_beta by CFAP58 expression — SKCM

Explore this box plot interactively →