CFAP53

Across TCGA patient cohorts, CFAP53 mutation is significantly associated with the RNA expression of many other genes, with 3,140 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CFAP53-associated genes across cancer lineages are MIR1237, LINC00273, and NDUFA4P2. Each is linked with CFAP53 in more than 2 cancer types. Because this analysis shows association rather than direction, both CFAP53-to-partner and partner-to-CFAP53 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR1237 grouped by CFAP53-low versus CFAP53-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CFAP53→partner) and Y-score (partner→CFAP53) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR1237 →	+0.079	+3.054	<.001	.005	3	3
SKCM	LINC00273 →	+0.012	+2.089	<.001	.008	3	3
SKCM	NDUFA4P2 →	+0.054	+2.300	.001	.002	3	2
SKCM	PDXP →	+0.555	+2.128	.001	.009	3	2
SKCM	ARPC4 →	+0.369	+2.102	<.001	<.001	3	2
SKCM	MTFP1 →	+0.634	+2.089	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,140 associations by consensus.

MIR1237 by CFAP53 expression — SKCM

Explore this box plot interactively →