CFAP53

Across TCGA patient cohorts, CFAP53 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CFAP53-associated genes across cancer lineages are eIF4G, A-Raf_pS299, and TFRC. Each is linked with CFAP53 in more than 1 cancer types. Because this analysis shows association rather than direction, both CFAP53-to-partner and partner-to-CFAP53 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4G grouped by CFAP53-low versus CFAP53-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CFAP53→partner) and Y-score (partner→CFAP53) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4G →	+0.319	+3.169	.007	.018	3	2
SKCM	A-Raf_pS299 →	-0.114	-3.000	.042	.034	3	2
UCEC	TFRC →	+0.524	+1.678	.010	.023	3	2
UCEC	Cyclin-B1 →	+0.707	+2.584	<.001	.001	3	2
UCEC	14-3-3_beta →	-0.081	-2.558	.035	.010	3	1
UCEC	ERK2 →	+0.184	+1.678	.012	.023	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

eIF4G by CFAP53 expression — UCEC

Explore this box plot interactively →