CFAP300

Across TCGA patient cohorts, CFAP300 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CFAP300-associated genes across cancer lineages are 14-3-3_beta, EGFR, and A-Raf_pS299. Each is linked with CFAP300 in more than 1 cancer types. Because this analysis shows association rather than direction, both CFAP300-to-partner and partner-to-CFAP300 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by CFAP300-low versus CFAP300-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CFAP300→partner) and Y-score (partner→CFAP300) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.130	-2.432	.002	.018	3	1
UCEC	EGFR →	-0.212	-2.321	.001	.034	3	1
UCEC	A-Raf_pS299 →	-0.176	-3.584	<.001	.002	3	1
UCEC	GSK-3a-b_pS21_S9 →	+0.471	+2.321	.009	.033	3	1
UCEC	JNK2 →	+0.176	+1.700	.037	.044	3	1
UCEC	Myosin-IIa_pS1943 →	+0.221	+1.713	.011	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

14-3-3_beta by CFAP300 expression — UCEC

Explore this box plot interactively →