CFAP251

Across TCGA patient cohorts, CFAP251 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CFAP251-associated genes across cancer lineages are PCNA, Caspase-7-cleavedD198, and C-Raf. Each is linked with CFAP251 in more than 2 cancer types. Because this analysis shows association rather than direction, both CFAP251-to-partner and partner-to-CFAP251 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by CFAP251-low versus CFAP251-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CFAP251→partner) and Y-score (partner→CFAP251) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.264	+1.716	<.001	.003	3	3
COAD	Caspase-7-cleavedD198 →	+1.459	+2.593	<.001	.006	3	3
UCEC	C-Raf →	+0.162	+1.847	<.001	.007	3	3
UCEC	Cyclin-E2 →	+0.173	+2.000	.001	<.001	3	3
SKCM	ASNS →	+0.439	+2.459	.034	.020	3	3
COAD	EGFR_pY1068 →	-0.366	-3.000	.007	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

PCNA by CFAP251 expression — UCEC

Explore this box plot interactively →