CFAP20DC

Across TCGA patient cohorts, CFAP20DC mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CFAP20DC-associated genes across cancer lineages are MEK1, EGFR_pY1068, and mTOR_pS2448. Each is linked with CFAP20DC in more than 1 cancer types. Because this analysis shows association rather than direction, both CFAP20DC-to-partner and partner-to-CFAP20DC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by CFAP20DC-low versus CFAP20DC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CFAP20DC→partner) and Y-score (partner→CFAP20DC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.438	+2.584	<.001	<.001	3	2
UCEC	EGFR_pY1068 →	-0.281	-2.201	<.001	<.001	3	2
UCEC	mTOR_pS2448 →	-0.146	-2.395	.003	.003	3	2
UCEC	PDCD4 →	-0.579	-3.700	<.001	.001	3	2
UCEC	Rad50 →	-0.164	-1.584	.043	.009	3	2
UCEC	Shc_pY317 →	-0.168	-2.201	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

MEK1 by CFAP20DC expression — UCEC

Explore this box plot interactively →