CFAP161

Across TCGA patient cohorts, CFAP161 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CFAP161-associated genes across cancer lineages are FOXO3a, GSK-3_pS9, and MAPK_pT202_Y204. Each is linked with CFAP161 in more than 1 cancer types. Because this analysis shows association rather than direction, both CFAP161-to-partner and partner-to-CFAP161 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a grouped by CFAP161-low versus CFAP161-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CFAP161→partner) and Y-score (partner→CFAP161) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a →	+0.131	+2.820	.004	.035	3	1
UCEC	GSK-3_pS9 →	-0.433	-3.321	.017	.009	3	1
UCEC	MAPK_pT202_Y204 →	-0.454	-2.000	.032	.032	3	1
UCEC	MEK1 →	+0.324	+2.700	.049	.006	3	1
UCEC	PCNA →	+0.246	+3.169	.011	.018	3	1
UCEC	PDCD4 →	-0.737	-3.169	<.001	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

FOXO3a by CFAP161 expression — UCEC

Explore this box plot interactively →