CETP

Across TCGA patient cohorts, CETP mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CETP-associated genes across cancer lineages are ERK2, JNK_pT183_Y185, and MEK1. Each is linked with CETP in more than 1 cancer types. Because this analysis shows association rather than direction, both CETP-to-partner and partner-to-CETP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by CETP-low versus CETP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CETP→partner) and Y-score (partner→CETP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.210	+2.584	.019	.011	3	1
UCEC	JNK_pT183_Y185 →	-0.211	-3.459	.007	.005	3	1
UCEC	MEK1 →	+0.446	+3.321	.008	.010	2	2
UCEC	MSH2 →	-0.295	-2.584	.006	.011	3	1
UCEC	STAT3_pY705 →	-0.448	-3.321	<.001	.009	3	1
SKCM	SF2 →	-0.221	-3.584	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

ERK2 by CETP expression — UCEC

Explore this box plot interactively →