CETP

Across TCGA cell cohorts, CETP RNA expression is significantly associated with the go_rna of many other GO terms, with 2,264 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible CETP-associated GO terms across cancer lineages are Positive regulation of response to type II interferon, Positive regulation of type II interferon-mediated signaling pathway, and Negative regulation of immune response. Each is linked with CETP in more than 12 cancer types. Because this analysis shows association rather than direction, both CETP-to-partner and partner-to-CETP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of response to type II interferon grouped by CETP-low versus CETP-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CETP→partner) and Y-score (partner→CETP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of response to type II interferon →	+1.393	+0.139	<.001	<.001	3	13
BONE	Positive regulation of type II interferon-mediated signaling pathway →	+1.393	+0.139	<.001	<.001	3	13
BREAST	Negative regulation of immune response →	+0.072	+0.077	<.001	<.001	3	10
BREAST	Antigen processing and presentation of endogenous peptide antigen via MHC class I →	+0.319	+0.131	<.001	.001	3	9
OVARY	Positive regulation of defense response to virus by host →	+0.090	+0.121	.002	.005	3	9
UPPER_AERODIGESTIVE_TRACT	Viral gene expression →	+0.092	+0.133	.003	.007	2	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,264 associations by consensus.

Positive regulation of response to type II interferon by CETP expression — BONE

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