CETP

Across TCGA cell cohorts, CETP mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible CETP-associated genes across cancer lineages are PRAMEF20, OR7G2, and PNMA6F. Each is linked with CETP in more than 1 cancer types. Because this analysis shows association rather than direction, both CETP-to-partner and partner-to-CETP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAMEF20 grouped by CETP-low versus CETP-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CETP→partner) and Y-score (partner→CETP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PRAMEF20 →	+0.020	+6.022	<.001	.001	3	1
LUNG_NSCLC_LUAD	OR7G2 →	+0.012	+4.887	.004	.009	3	1
LUNG_NSCLC_LUAD	PNMA6F →	+0.012	+4.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

PRAMEF20 by CETP expression — LARGE_INTESTINE

Explore this box plot interactively →