CES5A

Across TCGA pan-cancer cohorts, CES5A Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated CES5A data layer compared with 26 for mass-spec protein.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher CES5A Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated CES5A expression acts as an unfavorable survival marker.

OV, LUSC, and HNSC are the cancer types where CES5A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	DFS	Median	All	0.104	0.541	<.001	18	view →
LUSC	OS	Median	II,III,IV	0.272	0.635	.005	15	view →
HNSC	DFS	Median	II,III,IV	0.194	0.661	.031	9	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
PRAD	DFS	Median	All	0.154	0.777	<.001	4	view →
SARC	DFS	Median	All	0.101	0.632	.011	3	view →
READ	OS	Median	All	0.281	0.830	.006	3	view →
STAD	OS	Median	III,IV	0.224	0.640	.021	3	view →
SKCM	DFS	Median	All	0.093	0.212	.012	2	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

CES5A–OV (DFS)

Open the OV breakdown →