CES5A

Across TCGA patient cohorts, CES5A mutation is significantly associated with the RNA expression of many other genes, with 1,963 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CES5A-associated genes across cancer lineages are MAP2K1, RRM2, and ZMYND19. Each is linked with CES5A in more than 3 cancer types. Because this analysis shows association rather than direction, both CES5A-to-partner and partner-to-CES5A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAP2K1 grouped by CES5A-low versus CES5A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CES5A→partner) and Y-score (partner→CES5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MAP2K1 →	+0.423	+2.032	.003	.005	3	4
SKCM	RRM2 →	+0.622	+3.195	.007	.009	3	4
UCEC	ZMYND19 →	+0.357	+2.617	.001	<.001	3	3
UCEC	DOLPP1 →	+0.503	+2.627	<.001	<.001	3	3
UCEC	CTU2 →	+0.515	+3.235	<.001	<.001	3	3
UCEC	YIF1A →	+0.347	+2.158	.004	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,963 associations by consensus.

MAP2K1 by CES5A expression — UCEC

Explore this box plot interactively →