CES5A

Across TCGA patient cohorts, CES5A mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CES5A-associated genes across cancer lineages are ATM, PDCD4, and 4E-BP1. Each is linked with CES5A in more than 3 cancer types. Because this analysis shows association rather than direction, both CES5A-to-partner and partner-to-CES5A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by CES5A-low versus CES5A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CES5A→partner) and Y-score (partner→CES5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.732	-3.893	<.001	<.001	3	4
LUAD	PDCD4 →	-0.567	-3.000	.009	.034	3	3
LUAD	4E-BP1 →	+0.492	+3.012	.001	.018	3	3
UCEC	eIF4E →	+0.158	+1.847	.041	.008	3	3
UCEC	PCNA →	+0.227	+2.459	.004	.018	3	2
LUAD	Stathmin →	+0.308	+3.000	<.001	.035	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

ATM by CES5A expression — UCEC

Explore this box plot interactively →