CES5A

Across TCGA cell cohorts, CES5A mutation is significantly associated with the drug of many other genes, with 19 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CES5A-associated genes across cancer lineages are Mirin, GSK1070916, and XMD14-99. Each is linked with CES5A in more than 1 cancer types. Because this analysis shows association rather than direction, both CES5A-to-partner and partner-to-CES5A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mirin grouped by CES5A-low versus CES5A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CES5A→partner) and Y-score (partner→CES5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Mirin →	+0.456	+2.646	.015	.047	3	1
LARGE_INTESTINE	GSK1070916 →	+0.797	+2.655	.006	.044	3	1
LARGE_INTESTINE	XMD14-99 →	+0.392	+2.652	.017	.045	3	1
LARGE_INTESTINE	Masitinib →	+0.567	+2.652	.007	.045	3	1
LARGE_INTESTINE	Tivozanib →	+0.236	+2.786	.036	.037	3	1
LARGE_INTESTINE	776928 →	+0.632	+2.649	.046	.046	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Mirin by CES5A expression — LARGE_INTESTINE

Explore this box plot interactively →