CES3

Across TCGA patient cohorts, CES3 mutation is significantly associated with the RNA expression of many other genes, with 3,348 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CES3-associated genes across cancer lineages are BUB3, SKA1, and CCNB2. Each is linked with CES3 in more than 2 cancer types. Because this analysis shows association rather than direction, both CES3-to-partner and partner-to-CES3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BUB3 grouped by CES3-low versus CES3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CES3→partner) and Y-score (partner→CES3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BUB3 →	+0.443	+3.162	<.001	<.001	3	3
COAD	SKA1 →	+0.798	+3.598	<.001	.001	3	3
SKCM	CCNB2 →	+0.778	+2.328	.001	.003	3	3
SKCM	ZMYND19 →	+0.485	+3.372	<.001	.004	3	3
SKCM	CIAO2B →	+0.457	+3.472	<.001	.002	3	3
SKCM	SAAL1 →	+0.551	+3.497	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,348 associations by consensus.

BUB3 by CES3 expression — UCEC

Explore this box plot interactively →