CES3

Across TCGA patient cohorts, CES3 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CES3-associated genes across cancer lineages are PCNA, GAPDH, and NF-kB-p65_pS536. Each is linked with CES3 in more than 2 cancer types. Because this analysis shows association rather than direction, both CES3-to-partner and partner-to-CES3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by CES3-low versus CES3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CES3→partner) and Y-score (partner→CES3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.295	+2.807	<.001	<.001	3	3
UCEC	GAPDH →	+0.495	+1.874	.010	.049	3	2
UCEC	NF-kB-p65_pS536 →	-0.408	-2.459	.012	.018	3	2
UCEC	PDCD4 →	-0.587	-2.700	<.001	.005	3	2
UCEC	TFRC →	+0.478	+1.925	.012	.005	3	2
UCEC	TIGAR →	+0.160	+1.952	.003	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

PCNA by CES3 expression — UCEC

Explore this box plot interactively →