CES3

Across TCGA cell cohorts, CES3 mutation is significantly associated with the RNA expression of many other genes, with 49 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CES3-associated genes across cancer lineages are ENPP6, USP17L4, and PHOX2B. Each is linked with CES3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CES3-to-partner and partner-to-CES3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ENPP6 grouped by CES3-low versus CES3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CES3→partner) and Y-score (partner→CES3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ENPP6 →	+0.053	+3.793	<.001	.007	3	1
LARGE_INTESTINE	USP17L4 →	+0.012	+4.217	.005	.001	3	1
BLOOD_Leukemia	PHOX2B →	+0.019	+3.687	<.001	<.001	3	1
BLOOD_Leukemia	PTPN5 →	+0.499	+4.197	<.001	<.001	3	1
BLOOD_Leukemia	ART4 →	+0.702	+3.708	.004	.003	3	1
BLOOD_Leukemia	C9 →	+0.988	+3.775	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

ENPP6 by CES3 expression — LARGE_INTESTINE

Explore this box plot interactively →