CES2

Across TCGA pan-cancer cohorts, CES2 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated CES2 data layer compared with 22 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher CES2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated CES2 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and COAD show a favorable association.

CCRCC, COAD, and PDAC are the cancer types where CES2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	III,IV	0.683	0.253	.009	55	view →
COAD	DFS	Tertile	All	1.000	0.910	.021	54	view →
PDAC	DFS	Quartile	All	0.580	0.328	.002	38	view →
LUAD	OS	Median	III,IV	0.298	0.808	.013	11	view →
HNSC	DFS	Median	III,IV	0.896	0.686	.004	7	view →
GBM	OS	Tertile	All	0.940	0.770	.021	4	view →
LSCC	DFS	Tertile	II,III,IV	0.854	0.541	.019	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

CES2–CCRCC (DFS)

Open the CCRCC breakdown →