Across TCGA cell cohorts, CES1 mutation is significantly associated with the RNA expression of many other genes, with 72 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CES1-associated genes across cancer lineages are INSL5, PZP, and OR1C1. Each is linked with CES1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CES1-to-partner and partner-to-CES1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CES1→partner) and Y-score (partner→CES1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	INSL5 →	+0.344	+3.626	<.001	.006	3	2
LUNG_SCLC	PZP →	+0.061	+4.044	<.001	.009	3	1
LUNG_SCLC	OR1C1 →	+0.053	+4.523	<.001	.003	3	1
LARGE_INTESTINE	GP9 →	+0.083	+3.196	<.001	.007	3	1
LARGE_INTESTINE	OR10W1 →	+0.016	+3.977	<.001	.001	3	1
LARGE_INTESTINE	FAM218A →	+0.395	+3.906	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 72 associations by consensus.

Exploration

CES1 survival (RNA) · tumor vs normal (RNA) · all CES1 data types