CERT1

Across TCGA pan-cancer cohorts, CERT1 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated CERT1 data layer compared with 19 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher CERT1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated CERT1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

CESC, COAD, and ACC are the cancer types where CERT1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Median	All	0.119	0.588	.045	6	view →
COAD	DFS	Median	All	0.223	0.696	.017	6	view →
ACC	OS	Median	All	0.118	0.624	.038	6	view →
PRAD	DFS	Median	All	0.085	0.774	.001	6	view →
LUAD	DFS	Median	IV	0.333	0.671	.048	6	view →
UCEC	DFS	Median	II,III,IV	0.906	0.306	.026	6	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

CERT1–CESC (OS)

Open the CESC breakdown →