CERT1

Across TCGA pan-cancer cohorts, CERT1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated CERT1 data layer compared with 19 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher CERT1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated CERT1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and HNSC show a favorable association.

LSCC, HNSC, and LUAD are the cancer types where CERT1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Median	III,IV	1.000	0.733	.007	12	view →
HNSC	DFS	Quartile	IV	0.934	0.562	.025	6	view →
LUAD	DFS	Median	III,IV	0.409	0.941	.010	3	view →
CCRCC	DFS	Quartile	III,IV	0.251	0.526	.045	2	view →
GBM	OS	Median	All	0.749	0.876	.022	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

CERT1–LSCC (OS)

Open the LSCC breakdown →