CERT1

Across TCGA patient cohorts, CERT1 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CERT1-associated genes across cancer lineages are EGFR_pY1068, SCD, and Src_pY416. Each is linked with CERT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CERT1-to-partner and partner-to-CERT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by CERT1-low versus CERT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CERT1→partner) and Y-score (partner→CERT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.309	-2.321	.014	.035	3	1
UCEC	SCD →	+0.132	+2.820	.017	.035	3	1
UCEC	Src_pY416 →	-0.276	-3.446	.022	.005	3	1
UCEC	Tuberin →	+0.349	+2.321	.009	.035	3	1
UCEC	Caspase-7-cleavedD198 →	+0.593	+2.827	.046	.035	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.616	+3.459	.015	.005	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

EGFR_pY1068 by CERT1 expression — UCEC

Explore this box plot interactively →