Across TCGA pan-cancer cohorts, CERS6-AS1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated CERS6-AS1 data layer.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher CERS6-AS1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated CERS6-AS1 expression acts as an unfavorable survival marker, although some lineages such as BRCA and CESC show a favorable association.

BRCA, UVM, and KIRC are the cancer types where CERS6-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	DFS	Median	All	0.932	0.877	<.001	78	view →
UVM	DFS	Quartile	II,III,IV	0.362	0.674	.003	43	view →
KIRC	OS	Tertile	All	0.549	0.695	.004	28	view →
PRAD	DFS	Quartile	All	0.667	0.853	.008	20	view →
CESC	DFS	Quartile	III,IV	0.894	0.497	.013	18	view →
ACC	DFS	Tertile	All	0.466	0.871	.013	16	view →
LIHC	OS	Median	III,IV	0.451	0.744	.003	14	view →
KIRP	DFS	Median	II,III,IV	1.000	0.510	.003	12	view →
LUSC	DFS	Quartile	III,IV	0.370	0.710	.012	12	view →
HNSC	OS	Tertile	All	0.625	0.814	.006	12	view →
LAML	DFS	Median	All	0.528	0.236	.007	10	view →
SKCM	OS	Tertile	III,IV	0.912	0.625	.004	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

Exploration

Same gene, other analysis: CERS6-AS1 tumor-vs-normal RNA expression · all CERS6-AS1 data types