CERS5

Across TCGA pan-cancer cohorts, CERS5 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated CERS5 data layer compared with 27 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher CERS5 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CERS5 expression acts as an unfavorable survival marker.

LSCC, CCRCC, and GBM are the cancer types where CERS5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	III,IV	0.328	0.938	<.001	38	view →
CCRCC	DFS	Tertile	III,IV	0.225	0.623	.021	10	view →
GBM	DFS	Quartile	All	0.288	0.537	.013	9	view →
LUAD	OS	Quartile	All	0.727	0.902	.032	3	view →
UCEC	OS	Median	All	0.920	1.000	.035	2	view →
HNSC	OS	Median	III,IV	0.948	1.000	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

CERS5–LSCC (DFS)

Open the LSCC breakdown →