CERS5

Across TCGA pan-cancer cohorts, CERS5 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of CERS5’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CERS5 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types CERS5 is over-expressed in tumor.

HNSC, CCRCC, and LSCC are the cancer types where CERS5 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CERS5 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	+0.723	<.001	11	view →
CCRCC	Male	All	+0.283	<.001	7	view →
LSCC	Male	All	+0.432	<.001	6	view →
COAD	All	All	+0.577	.020	2	view →
LUAD	Male	III,IV	+0.349	.036	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

CERS5–HNSC

Open the HNSC breakdown →