CERS5

Across TCGA patient cohorts, CERS5 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CERS5-associated genes across cancer lineages are Notch1, Rad50, and STAT5a. Each is linked with CERS5 in more than 1 cancer types. Because this analysis shows association rather than direction, both CERS5-to-partner and partner-to-CERS5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by CERS5-low versus CERS5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CERS5→partner) and Y-score (partner→CERS5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.189	+2.817	.007	.036	3	1
UCEC	Rad50 →	-0.266	-2.321	.029	.035	3	1
UCEC	STAT5a →	+0.431	+2.321	.032	.035	3	1
UCEC	ASNS →	+0.673	+2.321	<.001	.035	3	1
UCEC	Caspase-7-cleavedD198 →	+0.792	+3.459	.007	.005	3	1
UCEC	C-Raf →	+0.174	+3.459	.015	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Notch1 by CERS5 expression — UCEC

Explore this box plot interactively →