CERS5

Across TCGA cell cohorts, CERS5 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CERS5-associated genes across cancer lineages are PPP1R17, SULT6B1, and PTH. Each is linked with CERS5 in more than 1 cancer types. Because this analysis shows association rather than direction, both CERS5-to-partner and partner-to-CERS5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPP1R17 grouped by CERS5-low versus CERS5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CERS5→partner) and Y-score (partner→CERS5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PPP1R17 →	+0.036	+3.297	.009	.002	3	1
LARGE_INTESTINE	SULT6B1 →	+0.027	+3.562	<.001	.002	3	1
LARGE_INTESTINE	PTH →	+0.051	+3.514	<.001	.001	3	1
LARGE_INTESTINE	FANCD2OS →	+0.151	+3.667	<.001	.003	3	1
LARGE_INTESTINE	CALHM4 →	+0.090	+2.878	.002	.009	3	1
LARGE_INTESTINE	PRAMEF10 →	+0.395	+3.562	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

PPP1R17 by CERS5 expression — LARGE_INTESTINE

Explore this box plot interactively →