CERS2

Across TCGA patient cohorts, CERS2 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CERS2-associated genes across cancer lineages are FOXO3a_pS318_S321, Ku80, and PTEN. Each is linked with CERS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CERS2-to-partner and partner-to-CERS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by CERS2-low versus CERS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CERS2→partner) and Y-score (partner→CERS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.119	-2.584	.040	.011	3	1
UCEC	Ku80 →	+0.259	+3.469	.018	.002	3	1
UCEC	PTEN →	+0.442	+2.584	.017	.011	3	1
UCEC	RBM15 →	+0.304	+1.887	.040	.031	3	1
UCEC	beta-Catenin →	+0.538	+3.000	.022	.036	2	1
UCEC	JNK2 →	+0.327	+2.584	<.001	.011	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

FOXO3a_pS318_S321 by CERS2 expression — UCEC

Explore this box plot interactively →