CERS2

Across TCGA cell cohorts, CERS2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,428 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CERS2-associated GO terms across cancer lineages are Modified amino acid transport, Multi-pass transmembrane protein insertion into ER membrane, and Determination of left/right asymmetry in lateral mesoderm. Each is linked with CERS2 in more than 8 cancer types. Because this analysis shows association rather than direction, both CERS2-to-partner and partner-to-CERS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Modified amino acid transport grouped by CERS2-low versus CERS2-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CERS2→partner) and Y-score (partner→CERS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Modified amino acid transport →	+0.056	+0.719	<.001	<.001	3	9
LUNG_SCLC	Multi-pass transmembrane protein insertion into ER membrane →	+0.103	+0.610	<.001	.003	3	7
LARGE_INTESTINE	Determination of left/right asymmetry in lateral mesoderm →	+0.160	+0.394	<.001	<.001	3	7
LUNG_NSCLC_LUSC	Flavin-containing compound metabolic process →	+0.169	+0.844	.004	.006	3	7
UPPER_AERODIGESTIVE_TRACT	Regulation of microtubule polymerization →	+0.059	+0.631	.005	.006	3	7
LUNG_NSCLC_LUSC	Negative regulation of CD8-positive, alpha-beta T cell differentiation →	+0.246	+0.808	.003	.009	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,428 associations by consensus.

Modified amino acid transport by CERS2 expression — LUNG_NSCLC_LUAD

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