Across TCGA patient cohorts, CERS1 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CERS1-associated genes across cancer lineages are 14-3-3_beta, EGFR_pY1068, and eIF4E. Each is linked with CERS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CERS1-to-partner and partner-to-CERS1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CERS1→partner) and Y-score (partner→CERS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.104	-2.973	.017	.035	3	1
UCEC	EGFR_pY1068 →	-0.247	-2.115	.024	.019	3	1
UCEC	eIF4E →	+0.240	+2.335	.009	.018	3	1
UCEC	ERK2 →	+0.210	+3.321	.012	.009	3	1
UCEC	FOXO3a_pS318_S321 →	-0.110	-2.575	.044	.010	3	1
UCEC	JNK_pT183_Y185 →	-0.248	-2.794	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Exploration

CERS1 survival (RNA) · tumor vs normal (RNA) · all CERS1 data types