CERNA1

Across TCGA pan-cancer cohorts, CERNA1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of CERNA1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CERNA1 RNA is repressed in tumor relative to normal tissue. In most cancer types CERNA1 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and LIHC are the cancer types where CERNA1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CERNA1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−0.470	<.001	12	view →
KICH	Male	All	−0.898	<.001	8	view →
LIHC	All	All	+0.552	<.001	7	view →
HNSC	Male	III,IV	+0.373	<.001	7	view →
UCEC	All	All	−0.693	<.001	6	view →
BRCA	All	III,IV	−0.499	<.001	6	view →
KIRP	Male	All	−0.430	<.001	6	view →
COAD	All	II,III,IV	−0.129	.009	4	view →
CHOL	All	All	+0.965	<.001	3	view →
LUAD	All	All	+0.205	.025	3	view →
PRAD	All	All	−0.409	<.001	2	view →
THCA	Male	All	−0.277	.039	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

CERNA1–KIRC

Open the KIRC breakdown →