Across TCGA patient cohorts, CERKL mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CERKL-associated genes across cancer lineages are TSC1, Paxillin, and Caspase-7-cleavedD198. Each is linked with CERKL in more than 2 cancer types. Because this analysis shows association rather than direction, both CERKL-to-partner and partner-to-CERKL results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CERKL→partner) and Y-score (partner→CERKL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TSC1 →	-0.393	-3.161	.003	.019	3	3
UCEC	Paxillin →	+0.238	+2.331	.010	.003	3	2
UCEC	Caspase-7-cleavedD198 →	+0.651	+1.925	.002	.005	3	2
UCEC	4E-BP1 →	+0.274	+2.614	.004	.005	3	2
UCEC	C-Raf →	+0.169	+3.459	.001	<.001	3	2
COAD	Di-Ras3 →	-0.213	-3.000	.026	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

Exploration

CERKL survival (RNA) · tumor vs normal (RNA) · all CERKL data types