Across TCGA cell cohorts, CERKL mutation is significantly associated with the RNA expression of many other genes, with 31 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CERKL-associated genes across cancer lineages are CRYGD, AMELY, and MIOX. Each is linked with CERKL in more than 1 cancer types. Because this analysis shows association rather than direction, both CERKL-to-partner and partner-to-CERKL results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CERKL→partner) and Y-score (partner→CERKL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CRYGD →	+0.707	+5.415	<.001	.004	3	1
SKIN	AMELY →	+0.022	+5.415	<.001	.004	3	1
LARGE_INTESTINE	MIOX →	+0.358	+3.241	<.001	.007	3	1
LARGE_INTESTINE	ASPN →	+0.034	+2.600	.003	.006	3	1
LARGE_INTESTINE	MRPL42 →	+0.684	+3.087	.001	.006	3	1
LARGE_INTESTINE	SIRT1 →	+0.729	+3.064	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

Exploration

CERKL survival (RNA) · tumor vs normal (RNA) · all CERKL data types