CERK

Across TCGA pan-cancer cohorts, CERK mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated CERK data layer compared with 26 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CERK mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CERK expression acts as an unfavorable survival marker.

HNSC, LUAD, and GBM are the cancer types where CERK mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.523	0.851	.004	34	view →
LUAD	DFS	Quartile	II,III,IV	0.211	0.807	.024	3	view →
GBM	OS	Quartile	All	0.353	0.736	.017	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

CERK–HNSC (DFS)

Open the HNSC breakdown →