CERCAM

Across TCGA patient cohorts, CERCAM mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CERCAM-associated genes across cancer lineages are eEF2, ERK2, and MEK1. Each is linked with CERCAM in more than 1 cancer types. Because this analysis shows association rather than direction, both CERCAM-to-partner and partner-to-CERCAM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by CERCAM-low versus CERCAM-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CERCAM→partner) and Y-score (partner→CERCAM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.312	+1.906	.030	.016	3	1
UCEC	ERK2 →	+0.273	+3.700	<.001	.001	3	1
UCEC	MEK1 →	+0.402	+2.321	.006	.033	3	1
UCEC	MSH2 →	-0.240	-2.433	.009	.018	3	1
UCEC	p27_pT198 →	+0.096	+1.906	.026	.016	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.361	-2.459	.046	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

eEF2 by CERCAM expression — UCEC

Explore this box plot interactively →