CEP85

Across TCGA patient cohorts, CEP85 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CEP85-associated genes across cancer lineages are PRDX1, c-Met_pY1235, and 4E-BP1. Each is linked with CEP85 in more than 2 cancer types. Because this analysis shows association rather than direction, both CEP85-to-partner and partner-to-CEP85 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRDX1 grouped by CEP85-low versus CEP85-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CEP85→partner) and Y-score (partner→CEP85) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRDX1 →	+0.149	+2.321	.044	.033	3	3
UCEC	c-Met_pY1235 →	+0.096	+2.321	<.001	.001	3	2
UCEC	4E-BP1 →	+0.365	+3.700	<.001	.001	3	2
UCEC	eEF2 →	+0.398	+2.584	.001	.010	3	1
UCEC	EGFR_pY1068 →	-0.345	-2.807	<.001	<.001	3	1
UCEC	ERK2 →	+0.222	+1.925	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

PRDX1 by CEP85 expression — UCEC

Explore this box plot interactively →