CEP57L1

Across TCGA cell cohorts, CEP57L1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,947 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CEP57L1-associated GO terms across cancer lineages are Regulation of mitotic sister chromatid separation, Negative regulation of ubiquitin protein ligase activity, and Regulation of chromosome separation. Each is linked with CEP57L1 in more than 18 cancer types. Because this analysis shows association rather than direction, both CEP57L1-to-partner and partner-to-CEP57L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of mitotic sister chromatid separation grouped by CEP57L1-low versus CEP57L1-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CEP57L1→partner) and Y-score (partner→CEP57L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Regulation of mitotic sister chromatid separation →	+0.141	+0.801	<.001	<.001	3	19
KIDNEY	Negative regulation of ubiquitin protein ligase activity →	+0.224	+0.766	<.001	.002	3	19
OESOPHAGUS	Regulation of chromosome separation →	+0.149	+0.943	.004	<.001	3	19
UPPER_AERODIGESTIVE_TRACT	Regulation of mitotic metaphase/anaphase transition →	+0.134	+1.000	<.001	<.001	3	19
PANCREAS	Negative regulation of mitotic metaphase/anaphase transition →	+0.164	+1.055	<.001	<.001	3	18
STOMACH	Regulation of nuclear division →	+0.113	+1.127	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,947 associations by consensus.

Regulation of mitotic sister chromatid separation by CEP57L1 expression — KIDNEY

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